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Beginner’s guide to comparative bacterial genome analysis using next-generation sequence data

David J Edwards and Kathryn E Holt*

Microbial Informatics and Experimentation 2013, 3:2  doi:10.1186/2042-5783-3-2

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BG7 citation

Raquel Tobes   (2013-08-17 09:49)  Era7 Information Technologies SL email

BG7 is cited by the authors in this paragraph of the article:
��These include methods based on de novo discovery of genes, such as Prokka[36] and DIYA[37], or programs that transfer annotation directly from closely related genomes, such as RATT[38] and BG-7[39].��

For clarification BG7 is not based on the transference of annotations directly from closely related genomes. On the contrary BG7 is especially useful to detect unexpected genes not similar to genes from closely related genomes. BG7 is a de novo gene discovery and annotation system designed to manage bacterial genomes sequenced with NGS that is especially efficient for the quick annotation of genomes in a draft state. I include here a fragment of the abstract of the paper describing BG7 published in PLOS ONE:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049239

��BG7 is a new system for de novo bacterial, archaeal and viral genome annotation based on a new approach specifically designed for annotating genomes sequenced with next generation sequencing technologies. The system is versatile and able to annotate genes even in the step of preliminary assembly of the genome. It is especially efficient detecting unexpected genes horizontally acquired from bacterial or archaeal distant genomes, phages, plasmids, and mobile elements��.

BG7 paper includes comparison with other methods including RAST.

Competing interests

None declared

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